A Single Nucleotide Polymorphism in the MMP9 Promoter Affects Lung Cancer and Clinicopathological Properties in Iranian Population

Background: Lung cancer is the most common with 2,206,771 new cases in 2020 worldwide. MMP9 a member of matrix metalloproteinase family that also known as gelatinase B or IV type collagenase (92KD). through degrading Extracellular Matrix (ECM) and releasing growth factors has fundamental role tumorigenesis process. The C -1562 T SNP promoter increases expression susceptibility to lung cancer. Then, aim this present case-control study was investigate whether genetic variations gene may constitute markers for risk males positive history people Iran. Methods: This including 120 patients 100 healthy controls. Polymorphism region genotyped by PCR-RFLP assay. Odds Ratio (ORs) 95% Confidence Intervals (CIs) were estimated chi-square test from comparison genotypes between controls, using SPSS version 26.0. T-test Image J software used. Results: distribution C-1562T genotype significantly associated (Odds [OR] = 2.56, Interval [CI] 0.06-23.82). further stratification analyses shown increase Conclusion: Our results indicated polymorphism affects In addition, men allele (OR 3.94, CI 1.47-10`.55) TT 2.18, 1.03-4.59) exposure higher